[The results of the use of riboxin in the combined treatment of patients with pulmonary tuberculosis].

Abstract

Studies with infected animals showed that riboxine (inosine) having anabolic, antifibrotic, immunostimulating, antihypoxic and hepatoprotective activities, by the level of its therapeutic effect was not inferior to levamisole or sodium oxybutyrate and exceeded methyluracil. The evidence of the riboxine therapeutic effect mostly correlated with the antihypoxic activity. The use of riboxine at the early stages in the treatment of new cases with infiltrative destructive tuberculosis of the lungs of lobar and polysegmental extent promoted normalization of gaseous metabolism, significant improvement of capillary blood flow in the destructive zone, earlier and more frequent arresting of intoxication signs, sputum abacillation and elimination of the destructive cavities.

• Authors: A E Aleksandrova, L E Borisova, A V Vasil'ev
• Journal: Problemy tuberkuleza (Probl Tuberk) Issue 9 Pg. 28-33 ( 1989) ISSN: 0032-9533 [Print] Russia (Federation)
• Vernacular Title: Rezul'taty ispol'zovaniia riboksina v kompleksnoĭ terapii bol'nykh tuberkulezom legkikh.
• PMID: 2511573 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antitubercular Agents
• Inosine Nucleotides
• Inosine Diphosphate

Topics

• Adult
• Antitubercular Agents (therapeutic use)
• Drug Evaluation
• Drug Therapy, Combination
• Female
• Humans
• Inosine Diphosphate (therapeutic use)
• Inosine Nucleotides (therapeutic use)
• Lung (drug effects, physiopathology)
• Male
• Middle Aged
• Mycobacterium tuberculosis (isolation & purification)
• Respiratory Function Tests
• Sputum (microbiology)
• Tuberculosis, Pulmonary (drug therapy, microbiology, physiopathology)