Adjuvant chemotherapy in patients with completely resected small cell lung cancer: a retrospective analysis of 26 consecutive cases.

Abstract

OBJECTIVE:

Several clinical studies have demonstrated the efficacy and safety of adjuvant chemotherapy in patients with completely resected small cell lung cancer for a selected limited stage. However, it is unclear whether adjuvant chemotherapy is feasible in clinical practice. The objective of this study was to analyze the efficacy and safety of adjuvant chemotherapy for small cell lung cancer patients retrospectively in clinical practice.

METHODS:

From January 2002 to March 2012, 56 small cell lung cancer patients underwent surgery as initial therapy in our institute. Of these, 26 patients received adjuvant chemotherapy. The clinical data of patients who received adjuvant chemotherapy were retrospectively analyzed.

RESULTS:

The chemotherapy regimens were cisplatin and irinotecan in 16 patients, cisplatin and etoposide in 1 and carboplatin and etoposide in 9. Median follow-up time was 44.8 months. Nineteen (73%) patients received the full course of chemotherapy. Median recurrence-free survival was 21.4 months. Median survival time was not reached. There was no treatment-related death.

CONCLUSION:

Adjuvant chemotherapy may be generally safe and efficacious in selected small cell lung cancer patients.

• Authors: Hidenori Mizugaki, Yutaka Fujiwara, Noboru Yamamoto, Shigehiro Yagishita, Satoru Kitazono, Ayako Tanaka, Hidehito Horinouchi, Shintaro Kanda, Hiroshi Nokihara, Koji Tsuta, Hisao Asamura, Tomohide Tamura
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 44 Issue 9 Pg. 835-40 (Sep 2014) ISSN: 1465-3621 [Electronic] England
• PMID: 25097183 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected].

Chemical References

• Etoposide
• Irinotecan
• Carboplatin
• Cisplatin
• Camptothecin

Topics

• Adenocarcinoma (drug therapy, surgery)
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives)
• Carboplatin (administration & dosage)
• Carcinoma, Squamous Cell (drug therapy, surgery)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Disease-Free Survival
• Drug Administration Schedule
• Etoposide (administration & dosage)
• Female
• Humans
• Irinotecan
• Kaplan-Meier Estimate
• Lung Neoplasms (drug therapy, pathology, surgery)
• Male
• Middle Aged
• Neoplasm Staging
• Retrospective Studies
• Small Cell Lung Carcinoma (drug therapy, pathology, surgery)
• Treatment Outcome