[Study on prevention effect of huoluotongnao tablet on stroke (I)].

Abstract

OBJECTIVE:

To study the prevention effect of Huoluotongnao tablet on stroke.

METHODS:

Thrombosis on arteriovenous shunt rats model, platelet aggregation and hypertension combined high cholesterol rats model were used.

RESULTS:

Huoluotongnao tablet high and low dosage could inhibit the formation of arteriovenous thrombosis and platelet aggregation significantly ,the inhibition rate was 17.71%, 22.69%, 20.34% and 24.43%, respectively. Pretreatment of Huoluotongnao tablet could inhibit the formation of arteriovenous thrombosis significantly; The levels of CHOz in all treatment groups of hypertension combined high cholesterol rats model were decreased significantly,the levels of TGz and LDL-C were decreased in the high dosage group,the blood pressure was decreased in the middle dosage group. eta bL, eta P and eta r (B/P) were decreased in the middle and high dosage groups. eta bM, AI and CY were decreased in the middle and high dosage groups. Huoluotongnao tablet had effect on blood lipid,blood pressure and hemorheology and in a dose-dependence manner. Its minimal effecting dose was the middle dose. g/kg (crude drug) and has certain prevention effect on stroke.

CONCLUSION:

Huoluotongnao tablet's minimal effecting dose is 1.28

• Authors: Xiao-rong Zhan, Yi-hua Ma, Cheng Li, Pei-qing Liu, Ren-qiang Ma
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 36 Issue 12 Pg. 1983-7 (Dec 2013) ISSN: 1001-4454 [Print] China
• PMID: 25090686 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• Fibrinolytic Agents
• Tablets

Topics

• Animals
• Blood Viscosity (drug effects)
• Carotid Artery Thrombosis (blood, drug therapy)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drug Combinations
• Drugs, Chinese Herbal (administration & dosage, pharmacology)
• Female
• Fibrinolytic Agents (administration & dosage, pharmacology)
• Hemorheology (drug effects)
• Hypertension (complications)
• Intracranial Arteriosclerosis (drug therapy, etiology)
• Male
• Plants, Medicinal (chemistry)
• Platelet Aggregation (drug effects)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Stroke (drug therapy, prevention & control)
• Tablets