Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results.

Abstract

BACKGROUND/AIM:

Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented.

PATIENTS AND METHODS:

In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten additional factors (age, gender, performance status, tumor length, tumor stage (T-stage), nodes (N-stage), histology/grading, hemoglobin levels during radiotherapy, surgery) on survival and loco-regional control was evaluated up to 10 years following radio-chemotherapy.

RESULTS:

On multivariate analysis, improved survival was associated with low EPO-R expression (p=0.034) and hemoglobin levels during radiotherapy ≥ 12 g/dl (p=0.026). Low EPO expression was associated with survival on univariate (p=0.010) but not on multivariate analysis (p=0.42). On multivariate analysis, improved loco-regional control was significantly associated with hemoglobin levels during radiotherapy ≥ 12 g/dl (p<0.001).

CONCLUSION:

The long-term results confirm that hemoglobin levels during radiotherapy and tumor cell expression of EPO-R are significant prognostic factors in patients with locally advanced esophageal cancer.

• Authors: Dirk Rades, Amira Bajrovic, Steven E Schild, Christoph Thorns, Ergin Kilic
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 8 Pg. 4351-5 (Aug 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 25075070 (Publication Type: Journal Article)
• Copyright: Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Hemoglobins
• Receptors, Erythropoietin
• Erythropoietin
• Oxygen

Topics

• Adult
• Aged
• Erythropoietin (analysis)
• Esophageal Neoplasms (metabolism, mortality, pathology, radiotherapy)
• Female
• Hemoglobins (analysis)
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Oxygen (metabolism)
• Prognosis
• Receptors, Erythropoietin (analysis)
• Time Factors