Triphenylguanidine, a new (old?) rubber accelerator detected in surgical gloves that may cause allergic contact dermatitis.

Abstract

BACKGROUND:

Rubber accelerators are common contact allergens in healthcare personnel, owing to exposures from medical gloves.

OBJECTIVES:

To analyse glove extracts used for patch testing for the presence of guanidine-type accelerators, and to describe the results of patch testing with triphenylguanidine (TPG) in 2 cases of contact allergy and with TPG added to the rubber series.

MATERIALS AND METHODS:

Gas chromatography-mass spectrometry and liquid chromatography with ultraviolet detection were used for analysis of glove extracts. Patch tests were performed with guanidine accelerators detected in the extracts.

RESULTS:

TPG, an accelerator not previously reported as being present in rubber gloves, was found in the glove extracts. Patch testing with TPG showed relevant contact allergic reactions in patients with hand dermatitis caused by rubber gloves.

CONCLUSIONS:

Chemical analysis of extracts for patch testing is important in the identification of new possible allergens. In this case, a rubber accelerator previously not reported as a possible contact allergen was found in extracts of surgical gloves.

• Authors: Jakob Dahlin, Ola Bergendorff, Hilde K Vindenes, Monica Hindsén, Cecilia Svedman
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 71 Issue 4 Pg. 242-6 (Oct 2014) ISSN: 1600-0536 [Electronic] England
• PMID: 25041289 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Guanidines
• Rubber

Topics

• Adult
• Chromatography, Liquid
• Dermatitis, Allergic Contact (diagnosis, etiology)
• Dermatitis, Occupational (diagnosis, etiology)
• Female
• Gas Chromatography-Mass Spectrometry
• Gloves, Surgical (adverse effects)
• Guanidines (adverse effects, analysis)
• Hand Dermatoses (chemically induced, diagnosis)
• Health Personnel
• Humans
• Middle Aged
• Patch Tests
• Rubber (adverse effects, chemistry)