Abstract | OBJECTIVE: STUDY DESIGN: An experimental study at the University of Murcia. METHODS: 50 male Syrian hamsters (Mesocricetus auratus) were divided into five groups of ten: Group I (control group): 0.5% DMBA; Group II: 0.5% DMBA+1.1mg/15ml potassium apigenin; Group III: 05% DMBA+2.5mg/15ml cocoa catechins; Group IV: 0.5% DMBA+6mg/15ml eriocitrin; Group V: 0.5% DMBA+1.3mg/15ml rosmarinic acid. The flavonoids were administered orally. All the animals were sacrificed after 12 weeks. Macroscopic, microscopic and immunohistochemical ( PCNA and p53) analyses of the lesions were performed. RESULTS: All the groups treated with phenolic compounds showed lower incidences of tumour, greater differentiation and lower scores in the tumour invasion front grading system in comparison with the control group. Potassium apigenin and rosmarinic acid achieved the best results, the former considerably reduced the carcinoma tumour volumes developed and both significantly reduced the intensity and aggression of the tumours. Immunoexpression of PCNA and p53 were significantly altered during DMBA-induced oral carcinogenesis. CONCLUSIONS:
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Authors | B Baldasquin-Caceres, F J Gomez-Garcia, P López-Jornet, J Castillo-Sanchez, V Vicente-Ortega |
Journal | Archives of oral biology
(Arch Oral Biol)
Vol. 59
Issue 10
Pg. 1101-7
(Oct 2014)
ISSN: 1879-1506 [Electronic] England |
PMID | 25033381
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Cinnamates
- Depsides
- Flavanones
- Phenols
- Proliferating Cell Nuclear Antigen
- Tumor Suppressor Protein p53
- Apigenin
- Catechin
- eriocitrin
- rosmarinic acid
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Topics |
- Administration, Oral
- Administration, Topical
- Animals
- Apigenin
(administration & dosage, pharmacology)
- Cacao
- Catechin
(administration & dosage, pharmacology)
- Chemoprevention
(methods)
- Cinnamates
(administration & dosage, pharmacology)
- Cricetinae
- Depsides
(administration & dosage, pharmacology)
- Flavanones
(administration & dosage, pharmacology)
- Immunoenzyme Techniques
- Male
- Mouth Neoplasms
(pathology, prevention & control)
- Neoplasm Grading
- Phenols
(administration & dosage, pharmacology)
- Proliferating Cell Nuclear Antigen
(metabolism)
- Random Allocation
- Tumor Suppressor Protein p53
(metabolism)
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