Survival and recurrence patterns after neoadjuvant docetaxel, cisplatin, and 5-fluorouracil (DCF) for locally advanced esophagogastric adenocarcinoma.

Abstract

INTRODUCTION:

We have previously identified Docetaxel, Cisplatin, and 5FU (DCF) as a safe, tolerable, and effective regimen in the neoadjuvant setting for locally advanced adenocarcinoma (ADC) of the esophagus and esophagogastric junction (EGJ). We hypothesized that DCF combined with enhanced surgical control would result in a low rate of local or regional recurrence, and thus reviewed our outcomes with this treatment regimen.

METHODS:

A prospectively entered database of all esophageal and EGJ ADC patients resected at a high-volume referral center over 6 years (9/07-9/13) was reviewed for cases treated with curative intent neoadjuvant DCF followed by en bloc resection with extended lymphadenectomy (D2/D3). Recurrences was defined as locoregional (biopsy on endoscopy/regional lymph nodes (LNs)) and distant. Standard statistical techniques were used.

RESULTS:

Of 279 patients with ADC, 86 (85% male, mean age 63 years (interquartile range 56-70)) underwent preoperative DCF and curative intent resection for locally advanced ADC (cT3 93%; cN+ 69%) of the EGJ (54%) or distal esophagus (46%). After median follow-up of 40 months, the overall 5-year survival was 54% and 43 (52%) had recurred at a median time of 14 months. Sites of recurrence included locoregional only in 2 of 45 (4%), distant only in 40 of 45 (89%), and locoregional and distant in 3 of 45 (7%).

DISCUSSION:

The present study demonstrates favourable oncologic outcomes with low local/regional recurrence and an excellent overall 5-year survival after neoadjuvant DCF for esophageal and EGJ ADCs. Because the majority of recurrences were distant, our data support the notion that efforts to improve outcomes in these patients should concentrate on enhancing systemic, rather than local, therapy.

• Authors: Monisha Sudarshan, Thierry Alcindor, Steven Ades, Abdullah Aloraini, Marie van Huyse, Jamil Asselah, Marc David, Dominique Frechette, Sonia Brisson, Michael Thirlwell, Lorenzo Ferri
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 22 Issue 1 Pg. 324-30 (Jan 2015) ISSN: 1534-4681 [Electronic] United States
• PMID: 25023544 (Publication Type: Journal Article)

Chemical References

• Taxoids
• Docetaxel
• Cisplatin
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy, mortality, pathology)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, mortality, pathology)
• Cisplatin (administration & dosage)
• Docetaxel
• Esophageal Neoplasms (drug therapy, mortality, pathology)
• Esophagogastric Junction
• Female
• Fluorouracil (administration & dosage)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Neoplasm Grading
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local (drug therapy, mortality, pathology)
• Neoplasm Staging
• Prognosis
• Prospective Studies
• Retrospective Studies
• Stomach Neoplasms (drug therapy, mortality, pathology)
• Survival Rate
• Taxoids (administration & dosage)