The effects of bariatric surgery on colorectal cancer risk: systematic review and meta-analysis.

Abstract

Obesity is an established risk factor for colorectal cancer (CRC) but the effects of bariatric surgery on CRC incidence are uncertain. A systematic review of six electronic databases identified 3691 articles. Four observational studies met our inclusion criteria and results were pooled using a random effects model. Meta-analysis of these four studies revealed that bariatric surgery was associated with a significantly (p = 0.004) lower CRC incidence (RR = 0.73, 95 % confidence interval, 0.58 - 0.90) when compared with obese non-operated individuals, i.e., bariatric surgery is associated with a 27 % lower CRC risk. However the evidence base is limited and these findings should be confirmed by future studies with improved designs.

• Authors: Sorena Afshar, Seamus B Kelly, Keith Seymour, Jose Lara, Sean Woodcock, John C Mathers
• Journal: Obesity surgery (Obes Surg) Vol. 24 Issue 10 Pg. 1793-9 (Oct 2014) ISSN: 1708-0428 [Electronic] United States
• PMID: 25015708 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Topics

• Bariatric Surgery
• Colorectal Neoplasms (etiology, prevention & control)
• Humans
• Incidence
• Obesity (complications, surgery)
• Risk
• Risk Factors