Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells.

Abstract

We have efficiently synthesized albiziabioside A (1) together with its six disaccharide analogues through a linear synthesis, and evaluated their cytotoxicity against six different skin cancer cells. All of the analogues showed weak cytotoxicity, with the exception of compound 1, which exhibited strong cytotoxicity against A375 cells. Albiziabioside A can induce cell cycle arrest in both the S and G2/M phases. Moreover, albiziabioside A can induce A375 cell apoptosis via mitochondrial pathways involving a caspase cascade. These results provide for the first time a basic mechanism for the anticancer activity of 1.

• Authors: Gaofei Wei, Shuai Wang, Shanshan Cui, Jia Guo, Yongxiang Liu, Yang Liu, Maosheng Cheng
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 12 Issue 31 Pg. 5928-35 (Aug 21 2014) ISSN: 1477-0539 [Electronic] England
• PMID: 24985523 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amino Acid Chloromethyl Ketones
• Antineoplastic Agents
• Saponins
• albiziabioside A
• benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone

Topics

• Amino Acid Chloromethyl Ketones (pharmacology)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Apoptosis (drug effects, genetics)
• Cell Cycle Checkpoints (drug effects, genetics)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Melanoma (genetics, pathology)
• Membrane Potential, Mitochondrial (drug effects)
• Mitochondria (drug effects, metabolism)
• Saponins (chemical synthesis, chemistry, pharmacology)
• Signal Transduction (drug effects, genetics)