Abstract |
Primitive neuroectodermal tumors ( PNETs) exhibit chromosomal translocations in common with those of Ewing's sarcoma. They usually originate in bone or soft tissue but rarely arise in the vulva. The current case report presents a case of PNET originating in the vulva in a 60-year-old female, who previously underwent enucleation of a vulvar tumor in another hospital. The pathologist suspected a histopathological diagnosis of PNET, and simple vulvectomy and resection of the inguinal lymph nodes were performed. An ~3 cm mass recurred in the right side of the vulva four years following the initial surgery and the tumor was excised. The tumor comprised small, round-to-oval nuclei and stained positively for MIC-2, synaptophysin, neuron-specific enolase and neurofilament antibodies. To date, the patient remains alive and with no evidence of disease four years following multidisciplinary treatment, despite PNETs usually exhibiting a poor prognosis. This is due to the small tumor size and the absence of distant metastasis.
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Authors | Makiko Matsuda, Tomoyuki Ichimura, Mari Kasai, Makoto Murakami, Manabu Hoshi, Naoki Kawamura, Toshiyuki Sumi |
Journal | Oncology letters
(Oncol Lett)
Vol. 8
Issue 1
Pg. 187-189
(Jul 2014)
ISSN: 1792-1074 [Print] Greece |
PMID | 24959242
(Publication Type: Journal Article)
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