Epigenetic regulation of persistent pain.

Abstract

Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development or maintenance of persistent pain and possibly the transition of acute pain to chronic pain, thus shedding light in a direction for development of new therapeutics for persistent pain.

• Authors: Guang Bai, Ke Ren, Ronald Dubner
• Journal: Translational research : the journal of laboratory and clinical medicine (Transl Res) Vol. 165 Issue 1 Pg. 177-99 (Jan 2015) ISSN: 1878-1810 [Electronic] United States
• PMID: 24948399 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Histone Deacetylase Inhibitors
• Histones
• RNA, Untranslated

Topics

• Animals
• Chromatin Assembly and Disassembly
• Chronic Pain (drug therapy, genetics, metabolism)
• DNA Methylation
• Disease Models, Animal
• Epigenesis, Genetic
• Gene Expression Regulation
• Histone Deacetylase Inhibitors (therapeutic use)
• Histones (metabolism)
• Humans
• Inflammation (drug therapy, genetics, metabolism)
• Mice
• Neuralgia (genetics, metabolism)
• RNA, Untranslated (genetics, metabolism)
• Translational Research, Biomedical
• Visceral Pain (genetics, metabolism)