Pilomatrix
carcinoma is an extremely rare skin
tumor derived from basaloid cells in the hair follicles; it often exhibits locally aggressive behavior with a tendency toward local recurrence. The average age of occurrence is 45 years, and there appears to be a male to female incidence ratio of 4:1. Although pilomatrix
carcinomas are predominantly identified in the neck and scalp, there are studies in the literature reporting other
tumor development sites, including the upper extremities, torso and popliteal fossa. If diagnosed at an early stage, this malignant
tumor is generally treated with wide surgical resection. However, for the advanced-stage
tumors, there are no standard treatment procedures known to produce good results. The current study presents the case of a 76-year-old male with pilomatrix
carcinoma originating from the scalp with
metastases to the lung. The patient had a rapid and complete clinical response following an oral
combination chemotherapy regimen of
cyclophosphamide and
etoposide.