Abstract | BACKGROUND: Surveillance of children with acute otitis media (AOM) for nasopharyngeal colonization with Streptococcus pneumoniae before, during and after the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) indicated the near-complete elimination of PCV7 strains and the emergence of pneumococcal serotype 19A. METHODS: To determine effects of the introduction of 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal nasopharyngeal colonization, we obtained nasopharyngeal cultures from 228 children 6 through 23 of age months presenting with a new episode of AOM during 2012 and 2013 and enrolled in an ongoing clinical trial of antimicrobial efficacy. All children had received at least 2 doses of PCV13. The S. pneumoniae isolates were subjected to serotyping and testing for antimicrobial susceptibility. We compared the findings with results obtained in 3 earlier studies. RESULTS: We found nasopharyngeal colonization with S. pneumoniae in 113 (50%) of the children with AOM. PCV7 and PCV13 serotypes accounted for 2% and 12%, respectively, of the pneumococcal isolates. Of the 14 PCV13 isolates, 8 were serotype 19A. Nonvaccine serotypes accounted for 69% of the isolates. Most frequently occurring were subtypes of serotype 15 (23%) and serotype 35B (9%). Overall, 33% of the isolates were penicillin nonsusceptible, a proportion not significantly different from proportions found in our 3 earlier studies (26%, 36% and 37%, respectively). Serotypes 15 and 35B accounted for 51% of penicillin-nonsusceptible isolates. CONCLUSIONS: Expansion of contents of pneumococcal vaccine administered to children is followed by not-fully-predictable changes in nasopharyngeal pneumococcal colonization. Continued surveillance is required to help inform future vaccine development.
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Authors | Judith M Martin, Alejandro Hoberman, Jack L Paradise, Karen A Barbadora, Nader Shaikh, Sonika Bhatnagar, Timothy Shope, Stan L Block, Mary Ann Haralam, Marcia Kurs-Lasky, D Kathleen Colborn, Michael Green |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 33
Issue 11
Pg. e286-90
(Nov 2014)
ISSN: 1532-0987 [Electronic] United States |
PMID | 24911895
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- 13-valent pneumococcal vaccine
- Pneumococcal Vaccines
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Topics |
- Acute Disease
- Carrier State
(microbiology)
- Disk Diffusion Antimicrobial Tests
- Female
- Humans
- Infant
- Male
- Nasopharynx
(microbiology)
- Otitis Media
(microbiology)
- Penicillin Resistance
- Pneumococcal Infections
(microbiology)
- Pneumococcal Vaccines
- Serogroup
- Serotyping
- Streptococcus pneumoniae
(classification, isolation & purification)
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