Expression of E-cadherin and β-catenin in basaloid and conventional squamous cell carcinoma of the oral cavity: are potential prognostic markers?

Abstract

BACKGROUND:

Basaloid squamous cell carcinoma presents with a preference for the head and neck region, and shows a distinct aggressive behavior, with frequent local recurrences, regional and distant metastasis. The alterations in the cadherin-catenin complex are fundamental requirements for the metastasis process, and this is the first study to evaluate the immunostaining of E-cadherin and β-catenin in oral basaloid squamous cell carcinoma.

METHODS:

Seventeen cases of this tumor located exclusively in the mouth were compared to 26 cases of poorly differentiated squamous cell carcinoma and 28 cases of well to moderately differentiated squamous cell carcinoma matched by stage and tumor site. The immunostaining of E-cadherin and β-catenin were evaluated in the three groups and compared to their clinicopathological features and prognosis.

RESULTS:

For groups poorly differentiated squamous cell carcinoma and basaloid squamous cell carcinoma, reduction or absence of E-cadherin staining was observed in more than 80.0% of carcinomas, and it was statistically significant compared to well to moderately differentiated squamous cell carcinoma (p = .019). A strong expression of β-catenin was observed in 26.9% and 20.8% of well to moderately differentiated squamous cell carcinoma and poorly differentiated squamous cell carcinoma, respectively, and in 41.2% of basaloid squamous cell carcinoma. The 5-year and 10-year overall and disease-free survival rates demonstrated no significant differences among all three groups.

CONCLUSIONS:

The clinical and biological behavior of three groups of the oral cavity tumors evaluated are similar. E-cadherin and β-catenin immunostaining showed no prognostic value for basaloid and conventional squamous cell carcinomas.

• Authors: João Adolfo Costa Hanemann, Denise Tostes Oliveira, Suely Nonogaki, Inês Nobuko Nishimoto, Marina Lara de Carli, Gilles Landman, Luiz Paulo Kowalski
• Journal: BMC cancer (BMC Cancer) Vol. 14 Pg. 395 (Jun 03 2014) ISSN: 1471-2407 [Electronic] England
• PMID: 24893577 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Cadherins
• beta Catenin

Topics

• Biomarkers, Tumor (biosynthesis, genetics)
• Cadherins (biosynthesis, genetics)
• Carcinoma, Squamous Cell (genetics, pathology)
• Disease-Free Survival
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Middle Aged
• Mouth (pathology)
• Mouth Neoplasms (genetics, pathology)
• Neoplasm Recurrence, Local
• Prognosis
• beta Catenin (biosynthesis, genetics)