Survival and treatments in patients with incompletely resected thymoma.

Abstract

OBJECTIVES:

the objective of our study was to clarify survival and treatments in patients with incompletely resected thymoma.

METHODS:

between January 1991 and December 2012, 156 consecutive patients who underwent thymectomy with curative intent at Kyoto University Hospital, were evaluated retrospectively. Overall survival and progression-free survival were analyzed using the Kaplan-Meier method, comparing the complete resection group (n = 141) with the incomplete resection group (n = 15). Potentially relevant factors for overall survival and progression-free survival in patients with incompletely resected thymomas were analyzed using Cox proportional-hazard models.

RESULTS:

there was a significant difference in progression-free survival (p = 0.0012) but not in overall survival (p = 0.638) following thymectomy in the complete and incomplete resection groups. Adjuvant chemotherapy was performed in 6 (40%) patients and adjuvant radiotherapy in 6 (40%) in the incomplete resection group. In univariate analysis, younger age (p = 0.073) showed a tendency for better overall survival, and adjuvant chemotherapy (p = 0.071) showed a tendency for better progression-free survival.

CONCLUSION:

our results suggest that patients with incompletely resected thymomas can achieve comparable overall survival to those with completely resected thymomas. Adjuvant chemotherapy for incompletely resected thymomas tends to improve progression-free survival.

• Authors: Masatsugu Hamaji, Mitsugu Omasa, Fengshi Chen, Tetsu Yamada, Masaaki Sato, Toshi Menju, Toshihiko Sato, Akihiro Aoyama, Makoto Sonobe, Toru Bando, Hiroshi Date
• Journal: Asian cardiovascular & thoracic annals (Asian Cardiovasc Thorac Ann) Vol. 22 Issue 6 Pg. 712-8 (Jul 2014) ISSN: 1816-5370 [Electronic] England
• PMID: 24887927 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Chemotherapy, Adjuvant
• Disease-Free Survival
• Female
• Hospitals, University
• Humans
• Japan
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Neoplasm, Residual
• Proportional Hazards Models
• Radiotherapy, Adjuvant
• Retrospective Studies
• Risk Factors
• Thymectomy (adverse effects, mortality)
• Thymoma (mortality, pathology, surgery)
• Thymus Neoplasms (mortality, pathology, surgery)
• Time Factors
• Treatment Outcome
• Young Adult