The results from the published studies on the association between
hypoxia-inducible factor-1(Hif-1/HIF-1) polymorphisms and
cancer risk are conflicting. The common 1790G/A rs11549467) genetic polymorphism has been reported to be functional and may contribute to
genetic susceptibility to
cancers. However, the association between 1790G/A (rs11549467) and
cancer risk remains inconclusive.To better understand the role of 1790G/A (rs11549467) polymorphism in
cancer, we conducted this comprehensive meta-analysis encompassing 6337 cases and 9302 controls.Overall, the 1790G/A (rs11549467) genetic polymorphism was associated with higher
cancer risk. In the stratified analysis, significant associations were found between the Hif-1/HIF-1 1790G/A polymorphism and
lung cancer,
pancreatic cancer and
oral squamous cell carcinoma. We also observed that the AA genotype might modulate
lung cancer (OR=5.42[2.75-10.70]),
pancreatic cancer (OR=9.30[1.12-77.61]) and
oral squamous cell carcinoma (OSCC) (OR=13.32[1.57-112.75]) risk comparing with the GG genotype. Moreover, a significantly increased
cancer risk was found in homozygote comparison (AA vs. GG) and recessive genetic model (AA vs. AG/GG) among Caucasian population. When stratified by study design, significantly elevated susceptibility to
cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of
cancers except gynecologic
cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the
lung cancer,
pancreatic cancer and
oral squamous cell carcinoma (OSCC). The phenomenon also indicates that the SNP functions as a recessive mutation needs to be verified or linked with functional studies.