TFIIB-related factor 2 is associated with poor prognosis of nonsmall cell lung cancer patients through promoting tumor epithelial-mesenchymal transition.

Abstract

In this study, we found that increased BRF2 protein expression was prevalent in NSCLC. Overexpression of BRF2 correlated with abnormal expression of E-cadherin, N-cadherin, and snail. Additionally, expression of BRF2 was found to be an independent prognostic factor in NSCLC patients. Furthermore, we showed that targeted knockdown of BRF2 expression could inhibit the migratory and invasive abilities of NSCLC cells and induced loss of the epithelial-mesenchymal transition of NSCLC cells. These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program.

• Authors: Yu Tian, Ming Lu, Weiming Yue, Lin Li, Shuhai Li, Cun Gao, Libo Si, Lei Qi, Wensi Hu, Hui Tian
• Journal: BioMed research international (Biomed Res Int) Vol. 2014 Pg. 530786 ( 2014) ISSN: 2314-6141 [Electronic] United States
• PMID: 24738062 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BRF2 protein, human
• Transcription Factor TFIIIB

Topics

• Aged
• Carcinoma, Non-Small-Cell Lung (genetics, pathology)
• Epithelial-Mesenchymal Transition (genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Middle Aged
• Prognosis
• Transcription Factor TFIIIB (biosynthesis, genetics)