From mice to men: GEMMs as trial patients for new NSCLC therapies.

Abstract

Given the large socio-economic burden of cancer, there is an urgent need for in vivo animal cancer models that can provide a rationale for personalised therapeutic regimens that are translatable to the clinic. Recent developments in establishing mouse models that closely resemble human lung cancers involve the application of genetically engineered mouse models (GEMMs) for use in drug efficacy studies or to guide patient therapy. Here, we review recent applications of GEMMs in non-small cell lung cancer research for drug development and their potential in aiding biomarker discovery and understanding of biological mechanisms behind clinical outcomes and drug interactions.

• Authors: Sarah A Hayes, Amanda L Hudson, Stephen J Clarke, Mark P Molloy, Viive M Howell
• Journal: Seminars in cell & developmental biology (Semin Cell Dev Biol) Vol. 27 Pg. 118-27 (Mar 2014) ISSN: 1096-3634 [Electronic] England
• PMID: 24718320 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Biomarkers, Tumor

Topics

• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Biomarkers, Tumor (blood)
• Carcinoma, Non-Small-Cell Lung (blood, drug therapy, genetics)
• Drug Resistance, Neoplasm
• Drug Screening Assays, Antitumor
• Genetic Engineering
• Humans
• Lung Neoplasms (blood, drug therapy, genetics)
• Mice, Transgenic
• Molecular Targeted Therapy
• Neoplasms, Experimental (blood, drug therapy, genetics)
• Precision Medicine