Evaluation of 0.6% sodium alginate as a submucosal injection material in endoscopic submucosal dissection for early gastric cancer.

Abstract

BACKGROUND AND AIM:

We have focused on sodium alginate (SA) solution as a potential submucosal injection material for endoscopic submucosal dissection (ESD). A previous SA solution had high viscosity and problems such as difficult handling. After its properties were adjusted, SA solution was examined in vitro and its clinical safety was evaluated.

METHODS:

With 0.4% sodium hyaluronate (SH) solution as a control, catheter injectability and mucosa-elevating capacity of 0.3-0.8% SA solutions were evaluated. Next, 0.6% SA solution was used for ESD in 10 patients with early gastric cancer in a prospective clinical study.

RESULTS:

Compared with 0.4% SH solution, 0.6% SA solution exhibited no significant difference in catheter injectability but significant superiority in mucosa-elevating capacity. In the clinical study, no adverse events were observed in any patient.

CONCLUSION:

The safety of 0.6% SA solution as a submucosal injection material was confirmed and it is suggested that its efficacy should be investigated in a larger number of cases.

• Authors: Toru Kusano, Tsuyoshi Etoh, Tomonori Akagi, Yoshitake Ueda, Hidefumi Shiroshita, Kazuhiro Yasuda, Masahiro Satoh, Masafumi Inomata, Norio Shiraishi, Seigo Kitano
• Journal: Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society (Dig Endosc) Vol. 26 Issue 5 Pg. 638-45 (Sep 2014) ISSN: 1443-1661 [Electronic] Australia
• PMID: 24655031 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2014 The Authors. Digestive Endoscopy © 2014 Japan Gastroenterological Endoscopy Society.

Chemical References

• Alginates
• Biocompatible Materials
• Drug Carriers
• Hexuronic Acids
• Glucuronic Acid

Topics

• Aged
• Alginates (administration & dosage)
• Animals
• Biocompatible Materials (administration & dosage)
• Dissection (methods)
• Drug Carriers
• Early Detection of Cancer
• Female
• Gastric Mucosa (pathology, surgery)
• Gastroscopy (methods)
• Glucuronic Acid (administration & dosage)
• Hexuronic Acids (administration & dosage)
• Humans
• Injections
• Male
• Middle Aged
• Neoplasms, Experimental
• Prospective Studies
• Stomach Neoplasms (diagnosis, surgery)
• Swine
• Treatment Outcome