Spectral-domain optical coherence tomography evaluation of choroidal melanoma and nevus fine-needle aspiration biopsy incision sites.

Abstract

The authors present three cases in which spectral-domain optical coherence tomography was used to identify fine-needle aspiration biopsy incision sites. These biopsies were performed to obtain tissue for gene expression profiling of choroidal tumors. A transvitreal route into the apex of the tumors was utilized for the biopsies while the patients underwent pars plana vitrectomy, membrane peel, laser ablation, phacoemulsification with posterior chamber intraocular lens implantation, and intravitreal triamcinolone acetonide. To the best of the authors' knowledge, this is the first report documenting fine-needle aspiration biopsy incision wound architecture of the posterior segment with optical coherence tomography.

• Authors: Timothy G Murray, Aaron S Gold, Arnold M Markoe, Andrea Wildner, Azeema Latiff, Ernesto Bermudez, Fiona Ehlies
• Journal: Ophthalmic surgery, lasers & imaging retina (Ophthalmic Surg Lasers Imaging Retina) 2014 Mar-Apr Vol. 45 Issue 2 Pg. 165-8 ISSN: 2325-8179 [Electronic] United States
• PMID: 24635159 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2014, SLACK Incorporated.

Topics

• Aged
• Biopsy, Fine-Needle (methods)
• Choroid Neoplasms (genetics, pathology)
• Gene Expression Profiling
• Genes, Neoplasm
• Humans
• Male
• Melanoma (genetics, pathology)
• Middle Aged
• Nevus, Pigmented (genetics, pathology)
• Tomography, Optical Coherence (methods)