Abstract | BACKGROUND: Animal and clinical studies suggest a link between inflammation and oxidative stress. Because oxidative stress is an inherent part of inflammation, and inflammation is associated with behavioral aggression in lower mammals and humans, we hypothesized that markers of oxidative stress would be related to aggression in human subjects. In this case-control study, markers of oxidative stress and aggression were assessed in human subjects with histories of recurrent, problematic, impulsive aggressive behavior and in nonaggressive comparator subjects. METHODS: RESULTS: CONCLUSIONS: These data suggest a positive relationship between plasma markers of oxidative stress and aggression in human subjects. This finding adds to the complex picture of the central neuromodulatory role of aggression in human subjects.
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Authors | Emil F Coccaro, Royce Lee, David Gozal |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 79
Issue 2
Pg. 127-35
(Jan 15 2016)
ISSN: 1873-2402 [Electronic] United States |
PMID | 24582164
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- 8-epi-prostaglandin F2alpha
- 8-Hydroxy-2'-Deoxyguanosine
- Dinoprost
- Deoxyguanosine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Adult
- Aggression
(psychology)
- Biomarkers
(blood)
- Case-Control Studies
- Deoxyguanosine
(analogs & derivatives, blood)
- Diagnostic and Statistical Manual of Mental Disorders
- Dinoprost
(analogs & derivatives, blood)
- Disruptive, Impulse Control, and Conduct Disorders
(blood, psychology)
- Female
- Humans
- Impulsive Behavior
- Inflammation
(blood)
- Male
- Oxidative Stress
- Psychiatric Status Rating Scales
- Young Adult
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