Investigation of the Effect of Folic Acid Based Iron Oxide Nanoparticles on Human Leukemic CCRF-CEM Cell Line.

Abstract

BACKGROUND:

Nanoparticulate drug delivery systems have attracted significant attention in the field of cancer nanotechnology. This study determines the effect of folate-based Fe2O3 nanoparticles. This study aimed to decorate nanoparticles with folate (FA), a molecular ligand for 'active' targeting of cancerous cells and the application of modified-nanoparticles in cancer treatment.

MATERIALS AND METHODS:

The nanoparticles were prepared by a solvent evaporation and emulsification cross-linking method and anticancer activity of agent was evaluated on CCRF CEM cells, derived from human blood cancer samples.

RESULTS:

The physicochemical properties of the nanoparticles were characterized by various techniques, and uniform nanoparticles with an average particle size of 110±15 nm were obtained. Cytotoxicity tests showed that the SPIO-FA had higher cell toxicity, and confocal microscopy analysis confirmed excellent cellular uptake efficiency.

CONCLUSION:

These results indicate that FA based SPIO-NPs have potential uses as anticancer drug carriers and also have an enhanced anticancer effect.

• Authors: M Mehrabi, A Javid, A Hashemi, S Rezaei-Zarchi
• Journal: Iranian journal of pediatric hematology and oncology (Iran J Ped Hematol Oncol) Vol. 3 Issue 2 Pg. 47-53 ( 2013) ISSN: 2008-8892 [Print] Iran
• PMID: 24575269 (Publication Type: Journal Article)