Mycobacterium szulgai chronic multifocal osteomyelitis in an adolescent with inherited STAT1 deficiency.

Abstract

We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to the therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is the first description of M. szulgai osteomyelitis in an adolescent with a primary immunodeficiency.

• Authors: Oded Shamriz, Dan Engelhard, Andrea Psorn Rajs, Hasia Kaidar-Shwartz, Jean-Laurent Casanova, Diana Averbuch
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 32 Issue 12 Pg. 1345-7 (Dec 2013) ISSN: 1532-0987 [Electronic] United States
• PMID: 24569307 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibiotics, Antitubercular
• STAT1 Transcription Factor
• STAT1 protein, human

Topics

• Adolescent
• Antibiotics, Antitubercular (pharmacology, therapeutic use)
• Humans
• Male
• Microbial Sensitivity Tests
• Mycobacterium Infections, Nontuberculous (genetics, metabolism, microbiology)
• Nontuberculous Mycobacteria (drug effects, isolation & purification)
• Osteomyelitis (genetics, metabolism, microbiology)
• STAT1 Transcription Factor (deficiency, genetics)