The Janus face of cathelicidin in tumorigenesis.

Abstract

Cathelicidin is a host defense peptide with multiple innate immunity-related functions. Recent findings indicate that cathelicidin is frequently dysregulated in human cancers where it plays a paradoxical yet dominant role in the regulation of tumor malignancy. In this review, the regulation of malignant phenotypes by cathelicidin in relation to the activation of its receptors and intracellular signaling is discussed.

• Authors: W K K Wu, J J Y Sung, A S L Cheng, F K L Chan, S S M Ng, K F To, X J Wang, L Zhang, S H Wong, J Yu, C H Cho
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 21 Issue 21 Pg. 2392-400 ( 2014) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 24524763 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antimicrobial Cationic Peptides
• Cathelicidins

Topics

• Animals
• Antimicrobial Cationic Peptides (metabolism)
• Carcinogenesis
• Humans
• Neoplasms (blood supply, metabolism, pathology)
• Cathelicidins