Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study.

Abstract

Arsenic (As) exposure has been associated with both urologic malignancy and renal dysfunction; however, its association with hematuria is unknown. We evaluated the association between drinking water As exposure and hematuria in 7843 men enrolled in the Health Effects of Arsenic Longitudinal Study (HEALS). Cross-sectional analysis of baseline data was conducted with As exposure assessed in both well water and urinary As measurements, while hematuria was measured using urine dipstick. Prospective analyses with Cox proportional regression models were based on urinary As and dipstick measurements obtained biannually since baseline up to six years. At baseline, urinary As was significantly related to prevalence of hematuria (P-trend<0.01), with increasing quintiles of exposure corresponding with respective prevalence odds ratios of 1.00 (reference), 1.29 (95% CI: 1.04-1.59), 1.41 (95% CI: 1.15-1.74), 1.46 (95% CI: 1.19-1.79), and 1.56 (95% CI: 1.27-1.91). Compared to those with relatively little absolute urinary As change during follow-up (-10.40 to 41.17 μg/l), hazard ratios for hematuria were 0.99 (95% CI: 0.80-1.22) and 0.80 (95% CI: 0.65-0.99) for those whose urinary As decreased by >47.49 μg/l and 10.87 to 47.49 μg/l since last visit, respectively, and 1.17 (95% CI: 0.94-1.45) and 1.36 (95% CI: 1.10-1.66) for those with between-visit increases of 10.40 to 41.17 μg/l and >41.17 μg/l, respectively. These data indicate a positive association of As exposure with both prevalence and incidence of dipstick hematuria. This exposure effect appears modifiable by relatively short-term changes in drinking water As.

• Authors: Tyler R McClintock, Yu Chen, Faruque Parvez, Danil V Makarov, Wenzhen Ge, Tariqul Islam, Alauddin Ahmed, Muhammad Rakibuz-Zaman, Rabiul Hasan, Golam Sarwar, Vesna Slavkovich, Marc A Bjurlin, Joseph H Graziano, Habibul Ahsan
• Journal: Toxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 276 Issue 1 Pg. 21-7 (Apr 01 2014) ISSN: 1096-0333 [Electronic] United States
• PMID: 24486435 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Drinking Water
• Reagent Strips
• Water Pollutants, Chemical
• Arsenic

Topics

• Administration, Oral
• Adult
• Arsenic (administration & dosage, analysis, toxicity, urine)
• Arsenic Poisoning (epidemiology, etiology, physiopathology, urine)
• Bangladesh (epidemiology)
• Cohort Studies
• Cross-Sectional Studies
• Drinking Water (adverse effects, chemistry)
• Hematuria (etiology)
• Humans
• Incidence
• Longitudinal Studies
• Male
• Mass Screening
• Prevalence
• Proportional Hazards Models
• Prospective Studies
• Reagent Strips
• Rural Health
• Water Pollutants, Chemical (administration & dosage, analysis, toxicity, urine)
• Water Quality
• Water Wells (chemistry)