Abstract | BACKGROUND: METHODS: We retrospectively analysed 260 patients with ypN0 who received NAC followed by BCS and RT. Elective nodal irradiation was delivered to 136 (52.3%) patients. The effects of ENI on survival outcomes were evaluated. RESULTS: After a median follow-up period of 66.2 months (range, 15.6-127.4 months), 26 patients (10.0%) developed disease recurrence. The 5-year locoregional recurrence-free survival and disease-free survival (DFS) for all patients were 95.5% and 90.5%, respectively. Pathologic T classification (0-is vs 1 vs 2-4) and the number of LNs sampled (<13 vs ≥13) were associated with DFS (P=0.0086 and 0.0012, respectively). There was no significant difference in survival outcomes according to ENI. Elective nodal irradiation also did not affect survival outcomes in any of the subgroups according to pathologic T classification or the number of LNs sampled. CONCLUSIONS: ENI may be omitted in patients with ypN0 breast cancer after NAC and BCS. But until the results of the randomised trials are available, patients should be put on these trials.
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Authors | J M Noh, W Park, C-O Suh, K C Keum, Y B Kim, K H Shin, K Kim, E K Chie, S W Ha, S S Kim, S D Ahn, H S Shin, J H Kim, H-S Lee, N K Lee, S J Huh, D H Choi |
Journal | British journal of cancer
(Br J Cancer)
Vol. 110
Issue 6
Pg. 1420-6
(Mar 18 2014)
ISSN: 1532-1827 [Electronic] England |
PMID | 24481403
(Publication Type: Journal Article, Multicenter Study)
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Topics |
- Adult
- Aged
- Breast Neoplasms
(pathology, therapy)
- Disease-Free Survival
- Female
- Humans
- Lymph Nodes
(pathology, surgery)
- Lymphatic Irradiation
(methods)
- Lymphatic Metastasis
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Staging
- Retrospective Studies
- Young Adult
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