Correlation between radiation dose and histopathological findings in patients with gliblastoma treated with boron neutron capture therapy (BNCT).

Abstract

The purpose of this study was to clarify the correlation between the radiation dose and histopathological findings in patients with glioblastoma multiforme (GBM) treated with boron neutron capture therapy (BNCT). Histopathological studies were performed on specimens from 8 patients, 3 had undergone salvage surgery and 5 were autopsied. For histopathological cure of GBM at the primary site, the optimal minimal dose to the gross tumor volume (GTV) and the clinical target volume (CTV) were 68Gy(w) and 44Gy(w), respectively.

• Authors: T Kageji, Y Mizobuchi, S Nagahiro, Y Nakagawa, H Kumada
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 88 Pg. 20-2 (Jun 2014) ISSN: 1872-9800 [Electronic] England
• PMID: 24480727 (Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
• Copyright: Copyright © 2014. Published by Elsevier Ltd.

Chemical References

• 4-dihydroxyborylphenylalanine
• Borohydrides
• Boron Compounds
• Sulfhydryl Compounds
• mercaptoundecahydrododecaborate
• Phenylalanine

Topics

• Borohydrides (therapeutic use)
• Boron Compounds (therapeutic use)
• Boron Neutron Capture Therapy (methods)
• Brain Neoplasms (pathology, radiotherapy)
• Dose-Response Relationship, Radiation
• Glioblastoma (pathology, radiotherapy)
• Humans
• Neoplasm, Residual (pathology, prevention & control)
• Phenylalanine (analogs & derivatives, therapeutic use)
• Radiotherapy Dosage
• Statistics as Topic
• Sulfhydryl Compounds (therapeutic use)
• Survival Rate
• Treatment Outcome