Abstract | BACKGROUND: Different diffusion of different botulinum toxin type A (BoNTA) preparations may account for differences in outcomes in cosmetic clinical practice. OBJECTIVES: A double-blind, randomized, self-controlled study was performed to evaluate the diffusion characteristics of onabotulinumtoxinA and a Chinese type A botulinum toxin (CBTX-A). MATERIALS AND METHODS: Healthy volunteers (N = 20) were recruited to receive a 0.05-mL (2 U) injection of BoTNA at four forehead sites (medial forehead (subcutaneous (SC)) and temporal forehead (intradermal (ID))). On day 14, the Minor's iodine starch test was performed and photographs were taken for calculating the area and dimensions of anhydrotic area. RESULTS: CONCLUSION:
OnabotulinumtoxinA diffuses less than CBTX-A. ID injection technique may result in less diffusion than SC.
|
Authors | Hai-Yan Jiang, Shujun Chen, Jun Zhou, Kong Kwok Leung, Peiying Yu |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 40
Issue 2
Pg. 184-92
(Feb 2014)
ISSN: 1524-4725 [Electronic] United States |
PMID | 24438121
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Copyright | © 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc. |
Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
|
Topics |
- Adult
- Botulinum Toxins, Type A
(chemistry, pharmacokinetics)
- Double-Blind Method
- Female
- Forehead
- Humans
- Hypohidrosis
(chemically induced)
- Middle Aged
- Neuromuscular Agents
(chemistry, pharmacokinetics)
|