Background The spectrum of infundibular lesions is broad and distinct from sellar pathologies. In many cases, histology is needed to establish the correct diagnosis and determine the treatment approach. Methods Medical files of eight patients with distinct infundibular
tumors were reviewed. Histopathologically confirmed diagnosis included three pituicytomas, three
granular cell tumors, and two
pilocytic astrocytomas. Results Patients shared similar imaging findings and clinical symptoms, including
visual impairment (n = 5),
hypopituitarism (n = 4), and
headache (n = 4); one patient presented with disseminated disease and symptoms from spinal
metastases. All the pituicytomas, two
granular cell tumors, and one infundibular
pilocytic astrocytoma case underwent endoscopic endonasal surgery; gross total resection was achieved in five patients, three developed postoperative
diabetes insipidus, and two developed
hypopituitarism. No recurrences were observed. One
granular cell tumor patient was treated with gamma-knife radiosurgery after stereotactic biopsy; the
tumor remained stable in size for over 9 years. The infundibular
pilocytic astrocytoma patient who presented with spinal
metastases received
radiotherapy and systemic
chemotherapy. The overall mean follow-up period was 25.1 months. Conclusion Infundibular
tumors are rare entities that represent a diagnostic challenge. Histopathological examination is essential for definitive diagnosis. Surgery,
radiation therapy, and
chemotherapy all have a role in the management of these
tumors.