Chronic myelogenous leukemia after postoperative adjuvant S-1 therapy for rectal cancer: a case report.

Abstract

We report a case in which chronic myelogenous leukemia (CML) developed after postoperative adjuvant S-1 therapy for rectal cancer. A 56-year-old man was diagnosed with rectal adenocarcinoma, which was treated with abdominoperineal resection followed by a year of adjuvant S-1 therapy. At 39 postoperative months, he was diagnosed with CML. Although it remains unclear that CML that develops after treatment involving cytotoxic agents is treatment-related, clinicians should be aware of the possibility of CML developing after S-1 therapy.

• Authors: Masahiro Manabe, Takafumi Nishii, Junya Okita, Johji Nagasaki, Naonori Harada, Yasutaka Aoyama, Takeo Kumura, Tadanobu Ohta, Yoshio Furukawa, Kazuhiro Takeuchi, Atsuko Mugitani
• Journal: American journal of blood research (Am J Blood Res) Vol. 3 Issue 4 Pg. 286-9 ( 2013) ISSN: 2160-1992 [Print] United States
• PMID: 24396706 (Publication Type: Case Reports)