Gastrin-releasing peptide receptor expression in lung cancer.

Abstract

CONTEXT:

Gastrin-releasing peptide receptors (GRPRs) activate mitogen-activated protein kinase signaling pathway primarily through epidermal growth factor receptor activation and are under investigation as a molecular target because they are overexpressed in several solid tumors.

OBJECTIVE:

To determine GRPR expression in both non-small cell lung carcinoma and small cell lung carcinoma, comparing results with clinical stages and demographic data.

DESIGN:

We analyzed the immunohistochemical expression of GRPR in 200 non-small cell lung carcinoma and 38 small cell lung carcinoma archival cases from 2004 to 2008.

RESULTS:

Non-small cell lung carcinoma cases tended to be higher GRPR expressers at a rate of 62.5% (weak, moderate, and strong expression in 41.5%, 13.5%, and 7.5%, respectively), compared with 52.62% in small cell lung carcinoma cases (weak, moderate, and strong expression in 34.21%, 15.78%, and 2.63%, respectively; P = .30). In non-small cell lung carcinoma there was a trend for higher percentages of strong expression in adenocarcinoma cases (10%; P = .67), and in patients with advanced stages (III and IV; 9.43% and 6.9%; P = .01).

CONCLUSIONS:

To the best of our knowledge, this is the first study to demonstrate GRPR tissue expression in a large population of patients with lung cancer. Although GRPR expression was similar in small cell and non-small cell carcinoma, the expression was more pronounced in an advanced-stage lung cancer, particularly in adenocarcinoma cases, and may represent a potential target for the development of new treatment approaches in this population.

• Authors: Jane Mattei, Rosane D Achcar, Carlos H Cano, Bruno R Macedo, Luise Meurer, Brenda S Batlle, Steve D Groshong, Jane M Kulczynski, Rafael Roesler, Lissandra Dal Lago, Andre T Brunetto, Gilberto Schwartsmann
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 138 Issue 1 Pg. 98-104 (Jan 2014) ISSN: 1543-2165 [Electronic] United States
• PMID: 24377816 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Receptors, Bombesin

Topics

• Biomarkers, Tumor (analysis)
• Carcinoma, Non-Small-Cell Lung (metabolism, mortality, pathology)
• Carcinoma, Small Cell (metabolism, mortality, pathology)
• Female
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Lung Neoplasms (metabolism, mortality, pathology)
• Male
• Middle Aged
• Proportional Hazards Models
• Receptors, Bombesin (analysis, biosynthesis)
• Retrospective Studies