Abstract | OBJECTIVE: METHODS: Using the Netherlands Cohort Study (n = 58,279 men, aged 55 to 69 years), asbestos exposure was estimated by linkage to job-exposure matrices. After 17.3 years of follow-up, 132 pleural mesothelioma, 2324 lung cancer, and 166 laryngeal cancer cases were available. RESULTS: The multivariable-adjusted model showed overall positive associations between all levels of asbestos exposure and mesothelioma, lung cancer, and laryngeal cancer. Lung adenocarcinoma and glottis cancer showed only a positive association after prolonged higher asbestos exposure (hazard ratio per 10 years increment, 1.43 [95% confidence interval, 1.06 to 1.93] and 1.95 [95% confidence interval, 1.36 to 2.80], respectively). There was no statistically significant interaction between asbestos and smoking. CONCLUSIONS:
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Authors | Nadine S M Offermans, Roel Vermeulen, Alex Burdorf, R Alexandra Goldbohm, Timo Kauppinen, Hans Kromhout, Piet A van den Brandt |
Journal | Journal of occupational and environmental medicine
(J Occup Environ Med)
Vol. 56
Issue 1
Pg. 6-19
(Jan 2014)
ISSN: 1536-5948 [Electronic] United States |
PMID | 24351898
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Asbestos
(toxicity)
- Carcinoma
(epidemiology, etiology)
- Follow-Up Studies
- Humans
- Laryngeal Neoplasms
(epidemiology, etiology)
- Lung Neoplasms
(epidemiology, etiology)
- Male
- Mesothelioma
(epidemiology, etiology)
- Middle Aged
- Netherlands
(epidemiology)
- Occupational Exposure
(adverse effects)
- Pleural Neoplasms
(epidemiology, etiology)
- Prospective Studies
- Risk Factors
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