Asbestos

Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.

Networked: 5195 relevant articles (48 outcomes, 690 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carbone, Michele: 42 articles (10/2015 - 02/2002)
2.	Pass, Harvey I: 39 articles (10/2015 - 02/2002)
3.	Mossman, Brooke T: 35 articles (03/2015 - 02/2002)
4.	Kishimoto, Takumi: 33 articles (10/2015 - 02/2002)
5.	Toyokuni, Shinya: 26 articles (09/2015 - 11/2008)
6.	Otsuki, Takemi: 24 articles (12/2015 - 10/2006)
7.	Marinaccio, Alessandro: 24 articles (10/2015 - 09/2002)
8.	Mensi, Carolina: 24 articles (09/2015 - 07/2004)
9.	Testa, Joseph R: 23 articles (12/2015 - 01/2002)
10.	Nishimura, Yasumitsu: 23 articles (12/2015 - 02/2005)

Related Diseases

1.	Mesothelioma 01/01/2013 - "Malignant mesothelioma is an asbestos-related fatal disease with no effective cure. " 04/02/2010 - "Malignant mesothelioma is an asbestos-related fatal disease with no effective cure. " 01/01/2009 - "There is no effective cure or treatment for any of the lung or pleural asbestos related diseases; malignant mesothelioma has a median survival of just 6-12 months. " 08/01/1995 - "Most malignant mesothelioma cases are associated with pulmonary asbestos body (AB) counts significantly greater than those of the general population. " 08/15/2008 - "Some authors have suggested that the increase in mesothelioma rate with TSFE might be attenuated by clearance of asbestos from the lungs. "
2.	Neoplasms (Cancer) 01/01/2007 - "In addition there was a significant reduction of Asbestos and Hg from cancer cells, while markedly reduced normal cell telomere of lyg was increased to optimally high amounts of 500-530ng BDORTunits. " 06/01/1987 - "However, the work group does not believe that information was sufficient to assess the level of cancer risk associated with the ingestion and therefore, this potential hazard should not be discounted, and ingestion exposure to asbestos should be eliminated whenever possible." 12/02/2015 - "These results also indicated that asbestos exposure induced the reduction of anti-tumor immunity, and efforts to develop substances to reverse this reduction may be helpful in preventing the occurrence of asbestos-induced tumors. " 08/15/2008 - "The different trends for pleural and peritoneal cancer might be related to clearance of the asbestos from the workers' lungs." 07/01/2007 - "The different trends for pleural and peritoneal cancer might be related to clearance of the asbestos from the workers' lungs."
3.	Asbestosis 03/01/2010 - "Asbestosis represents a significant respiratory problem despite the improvement in the workplace hygiene and a decrease in use of asbestos. " 06/01/1989 - "Significantly greater numbers of BAL neutrophils were also found in asbestos-exposed workers without asbestosis than in either smoking or nonsmoking control subjects. " 01/01/2009 - "The radiographic gold-standard for diagnosis of asbestosis has been the plain chest radiograph, and in many asbestosis-screening clinics, chest radiograph abnormalities in conjunction with a history of asbestos exposure have been the mainstay of diagnosis. " 01/01/2011 - "First, the narrow definition of asbestosis forged by medical experts in interwar Britain helped shape a public perception of the asbestos issue as finite and controllable. " 07/01/1985 - "Bronchoalveolar lavage and clearance of 99m-Tc-DTPA in asbestos workers without evidence of asbestosis."
4.	Lung Neoplasms (Lung Cancer) 06/01/2014 - "This study aimed to determine whether CT scan screening in asbestos-exposed workers is effective in detecting asymptomatic lung cancer using a systematic review and meta-analysis. " 06/01/2014 - "CT scan screening in asbestos-exposed workers is effective in detecting asymptomatic lung cancer. " 01/01/1992 - ""Dose-response" dependence worked out by American scientists helped to reveal the linear dependence between carcinogenic risk factor, asbestos containing dust, and lung cancer formation, use it for basing the new MAC for asbestos containing dust taking into account the oncologic security." 06/01/1986 - "When asbestos was the only factor to be eliminated, the etiologic fraction estimate suggested a 23% reduction in the lung cancer incidence in the study population. " 01/01/2014 - "The results show that histology and location are not helpful in differentiating asbestos-related lung cancer. "
5.	Pulmonary Fibrosis (Hamman Rich Syndrome) 10/01/1990 - "This study suggests that the most common radiographic findings in asbestos-exposed, isolated pleural plaques are associated with a significant reduction in FEV1 and FVC, which cannot be attributed to the presence of radiographic and subradiographic pulmonary fibrosis." 11/01/2009 - "In this study, we demonstrate that Rac1 null mice are protected from asbestos-induced pulmonary fibrosis, as determined by histological and biochemical analysis. " 02/01/2005 - "The aim of the study was to determine the causes of impairment of ventilatory function and diffusing capacity in smoking asbestos-exposed workers (N=590) showing radiological pleural thickenings or pulmonary fibrosis. " 06/01/2004 - "The aim of this study was to determine criteria for independently associated features of pulmonary fibrosis in high-resolution computed tomograms among persons occupationally exposed to asbestos. " 08/01/1990 - "Although there is a correlation between the tissue concentration of asbestos fibers and the severity of pulmonary fibrosis, further studies of the mineralogic correlates of fiber-induced pulmonary fibrosis are needed. "

Related Drugs and Biologics

1.	Vitamin A (Retinol)
2.	beta Carotene (Betacarotene)
3.	Mercury
4.	Serpentine Asbestos (Chrysotile)
5.	Biological Markers (Surrogate Marker)
6.	DNA (Deoxyribonucleic Acid)
7.	Chromium
8.	alpha-Tocopherol
9.	Carcinogens
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Gamma Cameras (Gamma Camera)
3.	Orchiectomy (Orchidectomy)
4.	Chemoprevention
5.	Intraperitoneal Injections