Association between glycemic status and oral Candida carriage in patients with prediabetes.

Abstract

OBJECTIVE:

This study assessed the association between glycemic status and oral Candida carriage among patients with prediabetes.

STUDY DESIGN:

This was a comparative study of oral Candida carriage among individuals with prediabetes. Oral yeast samples were collected from 150 individuals: group A was 43 patients with prediabetes (fasting blood glucose levels and hemoglobin A1c, 100 to 125 mg/dL and ≥5%, respectively); group B was 37 individuals previously considered prediabetic but having fasting blood glucose levels <100 mg/dL and hemoglobin A1c <5%; and group C was 70 medically healthy individuals. Oral yeasts were identified using standard techniques. Unstimulated whole salivary flow rate and number of missing teeth were recorded.

RESULTS:

Oral Candida was isolated from 100% of patients with prediabetes and from 65.7% of control participants. Candida albicans carriage was higher among patients with prediabetes (48.7%) (P < .01) and patients in group A (51.2%) (P < .01) than among controls (25.7%). Candida carriage, unstimulated whole salivary flow rate, and number of missing teeth were similar in groups A and B.

CONCLUSIONS:

Oral Candida carriage was higher in patients with prediabetes than in controls and was independent of glycemic status in patients with prediabetes.

• Authors: Fawad Javed, Hameeda Bashir Ahmed, Abid Mehmood, Anwar Saeed, Khalid Al-Hezaimi, Lakshman P Samaranayake
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 117 Issue 1 Pg. 53-8 (Jan 2014) ISSN: 2212-4411 [Electronic] United States
• PMID: 24332327 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A

Topics

• Adult
• Blood Glucose (analysis)
• Candida albicans (isolation & purification)
• Candidiasis, Oral (complications)
• Case-Control Studies
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Logistic Models
• Male
• Mouth (microbiology)
• Prediabetic State (blood, complications)
• Saliva (metabolism)
• Surveys and Questionnaires