Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation.

Abstract

BACKGROUND:

We investigated whether circulating concentrations of soluble ST2, growth differentiation factor-15 (GDF-15), and high-sensitivity troponin I (hsTnI) are associated with incident atrial fibrillation (AF) and whether these biomarkers improve current risk prediction models including AF risk factors, B-type natriuretic peptide (BNP), and C-reactive protein (CRP).

METHODS:

We studied the relation between soluble ST2, GDF-15, and hsTnI and development of AF in Framingham Heart Study participants without prevalent AF. We used Cox proportional hazard regression analysis to examine the relation of incident AF during a 10-year follow-up period with each biomarker. We adjusted for standard AF clinical risk factors, BNP, and CRP.

RESULTS:

The mean age of the 3,217 participants was 59 ± 10 years, and 54% were women. During a 10-year follow-up, 242 participants developed AF. In age- and sex-adjusted models, GDF-15 and hsTnI were associated with risk of incident AF; however, after including the AF risk factors and BNP and CRP, only hsTnI was significantly associated with AF (hazard ratio per 1 SD of loge hsTnI, 1.12, 95% CI 1.00-1.26, P = .045). The c statistic of the base model including AF risk factors, BNP, and CRP was 0.803 (95% CI 0.777-0.830) and did not improve by adding individual or all 3 biomarkers. None of the discrimination and reclassification statistics were significant compared with the base model.

CONCLUSION:

In a community-based cohort, circulating hsTnI concentrations were associated with incident AF. None of the novel biomarkers evaluated improved AF risk discrimination or reclassification beyond standard clinical AF risk factors and biomarkers.

• Authors: Michiel Rienstra, Xiaoyan Yin, Martin G Larson, João D Fontes, Jared W Magnani, David D McManus, Elizabeth L McCabe, Erin E Coglianese, Michael Amponsah, Jennifer E Ho, James L Januzzi Jr, Kai C Wollert, Michael G Fradley, Ramachandran S Vasan, Patrick T Ellinor, Thomas J Wang, Emelia J Benjamin
• Journal: American heart journal (Am Heart J) Vol. 167 Issue 1 Pg. 109-115.e2 (Jan 2014) ISSN: 1097-6744 [Electronic] United States
• PMID: 24332149 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2014.

Chemical References

• Biomarkers
• GDF15 protein, human
• Growth Differentiation Factor 15
• IL1RL1 protein, human
• Interleukin-1 Receptor-Like 1 Protein
• Receptors, Cell Surface
• Natriuretic Peptide, Brain
• C-Reactive Protein

Topics

• Aged
• Atrial Fibrillation (blood, epidemiology)
• Biomarkers (blood)
• C-Reactive Protein (genetics)
• Female
• Growth Differentiation Factor 15 (blood)
• Humans
• Interleukin-1 Receptor-Like 1 Protein
• Male
• Middle Aged
• Natriuretic Peptide, Brain (genetics)
• Proportional Hazards Models
• Receptors, Cell Surface (blood)
• Risk Assessment
• Risk Factors