Hemagglutinin variants of influenza A(H1N1)pdm09 virus with reduced affinity for sialic acid receptors.

Abstract

In influenza A H1 virus, amino acids at position 190 and 225 of HA affect replication and transmission. In this study, we show that the mutation D190Y in the HA of influenza AH1N1pdm09 virus reduces the affinity of the virus for sialic acid receptors expressed at the surface of red blood cells from different species without affecting virus replication in MDCK cells.

• Authors: G Ayora-Talavera, L Cetina-Montejo, A Matos-Patrón, L Romero-Beltrán
• Journal: Archives of virology (Arch Virol) Vol. 159 Issue 5 Pg. 1207-11 (May 2014) ISSN: 1432-8798 [Electronic] Austria
• PMID: 24297491 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hemagglutinins
• Receptors, Cell Surface
• Sialic Acids
• sialic acid receptor

Topics

• Gene Expression Regulation, Viral (physiology)
• Hemagglutinins (genetics, metabolism)
• Influenza A Virus, H1N1 Subtype (genetics, metabolism)
• Mutation
• Receptors, Cell Surface (metabolism)
• Sialic Acids (metabolism)