Medicines of biogenic origin with micro-organic, regenerative and
analgesic properties are becoming more and more significant in the treatment of
burn wounds. These properties are found in apitherapeutics such as
propolis and honey--products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of
scar formation in experimentally evoked
burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of
propolis and honey. The results were compared with the
therapeutic effects obtained with
dermazin cream (1%
silver sulfadiazine). The level of
collagen was determined in the
wounds treated with 1% and 3% Sepropol and compared with the
collagen level in healthy skin and
wounds treated with
dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the
collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of
burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard
dermazin therapy.