Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastric cancer in central China.

Abstract

PURPOSE:

To investigate the association of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) gene polymorphisms with gastric cancer in Chinese Han population in central China.

METHODS:

A total of 304 patients with gastric cancer confirmed by histopathology and 421 unrelated healthy controls were studied. Gene polymorphisms of TRAIL (G1525A and C1595T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

RESULTS:

The frequency of the genotype carriers of TRAIL 1525A (GA + AA) and 1595T (CT + TT) was significantly lower in gastric cancer than in healthy controls (37.2% vs. 61.5%, P < 0.001, OR = 0.581, 95% CI 0.442 ~ 0.764; 36.2% vs. 62.0%, P < 0.001, OR = 0.570, 95% CI 0.433 ~ 0.750, respectively). Stratification analysis showed that both TRAIL 1525A (GA + AA) and 1595T (CT + TT) carriers were associated with poorly-differentiated gastric cancer compared to 1525GG genotype and 1595CC genotype (OR = 0.516, 95%CI 0.279 ~ 0.957, P = 0.026; OR = 0.395, 95%CI 0.207 ~ 0.753, P = 0.004, respectively).

CONCLUSIONS:

TRAIL G1525A and C1595T gene polymorphisms were significantly correlated with the susceptibility to gastric cancer in Chinese Han population in central China.

• Authors: Changgao Wang, Shufang Xu, Fengming Yi, Xiaobing Wang, Yuan Lei, Sha Huang, Rui Zhou, Bing Xia
• Journal: Pharmaceutical research (Pharm Res) Vol. 32 Issue 3 Pg. 762-8 (Mar 2015) ISSN: 1573-904X [Electronic] United States
• PMID: 24277417 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• TNF-Related Apoptosis-Inducing Ligand
• TNFSF10 protein, human

Topics

• Adenocarcinoma (ethnology, genetics, pathology)
• Apoptosis
• Asian People (genetics)
• Case-Control Studies
• Cell Differentiation
• Chi-Square Distribution
• China (epidemiology)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Humans
• Male
• Middle Aged
• Odds Ratio
• Phenotype
• Polymorphism, Genetic
• Risk Factors
• Stomach Neoplasms (ethnology, genetics, pathology)
• TNF-Related Apoptosis-Inducing Ligand (genetics)