Abstract | UNLABELLED: MATERIAL AND METHODS: The experimental group comprised 137 alcohol-dependent subjects. The control group was consisted of 50 healthy social drinkers. Ten biochemical assays were determined according to methods recommended by the provider of the tests - BioPredictive company. The scores were computed by the company according to the bilateral agreement. RESULTS: The diagnostic sensitivity and specificity were as follows: 61.9% and 93.9% for SteatoTest, 61.3% and 93.9% for FibroTest and 9.6% and 93.9% forAsh Test. The diagnostic power of Steato Test (A UC = 0.806) and FibroTest (AUC = 0.795) were significantly higher than the diagnostic power of AshTest (AUC = 0.626) but did not differ from each other. The probability of a positive test results of Steato Test and FibroTest is 10-times more likely in alcoholics than in healthy individuals. CONCLUSION: SteatoTest and FibroTest can be useful diagnostic tool for the detection of liver steatosis and fibrosis in alcohol-dependent patients but cannot differentiate of these clinical conditions.
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Authors | Łukasz Supronowicz, Ewa Wójtowicz, Bogdan Cylwik, Ewa Gruszewska, Lech Chrostek |
Journal | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
(Pol Merkur Lekarski)
Vol. 35
Issue 207
Pg. 148-50
(Sep 2013)
ISSN: 1426-9686 [Print] Poland |
Vernacular Title | Wartość diagnostyczna biochemicznych nieinwazyjnych biomarkerów w naduzywaniu alkoholu. |
PMID | 24224451
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Alcoholism
(blood, diagnosis)
- Biomarkers
(analysis)
- Female
- Humans
- Male
- Middle Aged
- Sensitivity and Specificity
- Substance Abuse Detection
(methods)
- Young Adult
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