The TNF-alpha -308G/A polymorphism is associated with type 2 diabetes mellitus: an updated meta-analysis.
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| Abstract |
The tumor necrosis factor (TNF)-alpha -308G/A polymorphism has long been suspected of being a gene variant that is associated with type 2 diabetes, but studies have reported conflicting outcomes. An updated meta-analysis was performed to investigate whether the TNF-alpha -308A variant is associated with an increased risk of type 2 diabetes. Statistical analyses were performed using Revman 5.0 and STATA 10.0 software. A total of 38 case-control studies in 38 articles were included. Statistical analyses of the results suggested that the TNF-alpha -308G/A polymorphism was associated with an increased risk of type 2 diabetes mellitus (OR = 1.21, 95 % CI 1.06-1.37, P = 0.003) in a dominant model, particularly for Asian carriers of the A mutation (GA+AA), who were shown to have a 39 % increased risk of type 2 diabetes (OR = 1.39, 95 % CI 1.11-1.74, P = 0.004) compared with wild-type (GG) subjects. However, no significant difference in diabetes risk was found between the mutant and wild-type genotypes in Caucasian subjects (OR = 1.08, 95 % CI 0.98-1.18, P = 0.12). This meta-analysis indicates that the TNF-alpha -308A variant could be a risk factor for the development of type 2 diabetes, particularly in Asian subjects. However, this association was not statistically significant in Caucasian subjects. More specified ethnical studies are required to reveal the detailed physiological characteristics of the TNF-alpha -308 G/A polymorphism.
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| Authors | Yuliang Zhao, Zheng Li, Ling Zhang, Yonggang Zhang, Yingying Yang, Yi Tang, Ping Fu |
| Journal | Molecular biology reports (Mol Biol Rep) Vol. 41 Issue 1 Pg. 73-83 (Jan 2014) ISSN: 1573-4978 [Electronic] Netherlands |
| PMID | 24197696 (Publication Type: Journal Article, Meta-Analysis) |
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