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Photodegradation of β-sheet amyloid fibrils associated with Alzheimer's disease by using polyoxometalates as photocatalysts.

Abstract
Herein we report that POMs can not only inhibit Aβ aggregation but also photodegrade Aβ, especially the oligomers, showing enhanced inhibition effects.
AuthorsMeng Li, Can Xu, Jinsong Ren, Enbo Wang, Xiaogang Qu
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 49 Issue 97 Pg. 11394-6 (Dec 18 2013) ISSN: 1364-548X [Electronic] England
PMID24165705 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amyloid
  • Tungsten Compounds
  • polyoxometalate I
  • Phosphotungstic Acid
Topics
  • Alzheimer Disease (metabolism, pathology)
  • Amyloid (chemistry, metabolism, toxicity)
  • Animals
  • Catalysis
  • Cell Survival (drug effects)
  • Humans
  • PC12 Cells
  • Phosphotungstic Acid (chemistry)
  • Photolysis
  • Protein Structure, Secondary
  • Rats
  • Tungsten Compounds (chemistry)
  • Ultraviolet Rays

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