Studies indicate the involvement of
brain-derived neurotrophic factor (
BDNF) in the pathogenesis of
Alzheimer's disease (AD). Decreased
BDNF levels may constitute a lack of trophic support and contribute to
cognitive impairment in AD. The benefits of acute and chronic physical exercise on
BDNF levels are well-documented in humans, however, exercise effects on
BDNF levels have not been analyzed in older adults with AD. The aim of this study was to investigate the effects of acute aerobic exercise on
BDNF levels in older adults with AD and to verify associations among
BDNF levels, aerobic fitness, and level of physical activity. Using a controlled design, twenty-one patients with AD (76.3 ± 6.2 years) and eighteen healthy older adults (74.6 ± 4.7 years) completed an acute aerobic exercise. The outcomes included measures of
BDNF plasma levels, aerobic fitness (treadmill grade, time to exhaustion, VO2, and maximal
lactate) and level of physical activity (Baecke Questionnaire Modified for the Elderly). The independent t-test shows differences between groups with respect to the
BDNF plasma levels at baseline (p = 0.04; t = 4.53; df = 37). In two-way ANOVA, a significant effect of time was found (p = 0.001; F = 13.63; df = 37), the aerobic exercise significantly increased
BDNF plasma levels in AD patients and healthy controls. A significant correlation (p = 0.04; r = 0.33) was found between
BDNF levels and the level of physical activity. The results of our study suggest that aerobic exercise increases
BDNF plasma levels in patients with AD and healthy controls. In addition to that,
BDNF levels had association with level of physical activity.