MIB-1 labeling index as a prognostic factor for patients with follicular lymphoma treated with rituximab plus CHOP therapy.
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| Abstract |
The MIB-1 labeling index, which is based on Ki67 immunostaining, is widely used to evaluate the proliferation of tumor cells in lymphoma. However, its clinical significance has not been fully assessed. We retrospectively evaluated the prognostic impact of the MIB-1 labeling index at the time of diagnosis, in 98 patients with follicular lymphoma (FL) grade 1-3b who were treated uniformly with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) therapy. The 5-year progression-free survival (PFS) for an MIB-1 labeling index of ≥10% (n = 60) and <10% (n = 38) was 35% and 61%, respectively (P = 0.015). The 5-year overall survival (OS) for an MIB-1 labeling index of ≥10% and <10% was 77% and 92%, respectively (P = 0.025). Pathological grading was not correlated with PFS or OS. In multivariate analysis, an MIB-1 labeling index of ≥10% was independently associated with poor PFS and OS. In conclusion, an MIB-1 labeling index of 10% is a useful cut-off level for predicting the prognosis of patients with FL.
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| Authors | Eri Yamamoto, Naoto Tomita, Seiji Sakata, Naoko Tsuyama, Kengo Takeuchi, Yuki Nakajima, Kazuho Miyashita, Takayoshi Tachibana, Hirotaka Takasaki, Masatsugu Tanaka, Chizuko Hashimoto, Hideyuki Koharazawa, Katsumichi Fujimaki, Jun Taguchi, Hiroshi Harano, Shigeki Motomura, Yoshiaki Ishigatsubo |
| Journal | Cancer science (Cancer Sci) Vol. 104 Issue 12 Pg. 1670-4 (Dec 2013) ISSN: 1349-7006 [Electronic] England |
| PMID | 24112697 (Publication Type: Journal Article) |
| Copyright | © 2013 Japanese Cancer Association. |
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