Cytogenetic response based on revised IPSS cytogenetic risk stratification and minimal residual disease monitoring by FISH in MDS patients treated with low-dose decitabine.

Abstract

The features of cytogenetic response have been not well described in myelodysplastic syndrome (MDS) patients receiving low-dose decitabine treatment. In this study, we observed and analyzed the response characteristics based on the revised IPSS (IPSS-R) cytogenetic risk stratification in eighty-seven MDS patients who received low-dose decitabine treatment (15-20 mg/M(2)/d×5/per course). Twenty-seven of 44 patients (61.3%) with abnormal karyotypes achieved a cytogenetic response, including 18 cases with complete cytogenetic response (cCR). The patients carrying poor or very poor karyotypes achieved better clinical and cytogenetic response than those with intermediate or good karyotypes. Among the patients with poor or very poor karyotypes, those carrying chromosome 7 aberrance showed a better treatment response than the other patients. Four patients (22.2%) of the patients who achieved clinical CR presented with a cytogenetic PR (partial response) or NR (no response). Over 5% of the clonal cells determined by FISH analysis were in the two patients who presented cytogenetic CR. Longer median OS (24 months) were observed in the patients who achieved a cytogenetic response than in those who did not (12 months) (P=0.007). The patients with poor or very poor karyotypes could achieve survival comparable to that of the patients with good or very good karyotypes after decitabine treatment (18 vs. 20 months, P=0.365). IPSS-R cytogenetic risk stratification could be used to predict the clinical and cytogenetic response to decitabine treatment in MDS patients, and the predicting effect may be related to chromosome 7 involvement. Analysis with FISH and G-banding should be available in determining the minimal residual disease in MDS patients after treatment.

• Authors: Xiao Li, Chunkang Chang, Qi He, Feng Xu, Qingxia Zhang, Lingyun Wu, Jiying Su, Xi Zhang, Liyu Zhou, Dong Wu, Luxi Song, Zheng Zhang
• Journal: Leukemia research (Leuk Res) Vol. 37 Issue 11 Pg. 1516-21 (Nov 2013) ISSN: 1873-5835 [Electronic] England
• PMID: 24084368 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antimetabolites, Antineoplastic
• Decitabine
• Azacitidine

Topics

• Abnormal Karyotype
• Adult
• Aged
• Antimetabolites, Antineoplastic (therapeutic use)
• Azacitidine (analogs & derivatives, therapeutic use)
• Chromosome Aberrations
• Cytogenetic Analysis
• Decitabine
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Humans
• In Situ Hybridization, Fluorescence
• Male
• Middle Aged
• Myelodysplastic Syndromes (drug therapy, genetics, mortality)
• Neoplasm, Residual (drug therapy, genetics, mortality)
• Prognosis
• Risk Assessment
• Survival Rate