Abstract | AIM: METHODS: Systematic searches of electronic databases such as PubMed, Medline, Web of knowledge and CNKI, as well as hand searching of the references of identified articles were performed. A total of 8979 subjects in 14 studies from 12 eligible publications were included in this meta-analysis (6 of 12 eligible studies were analyzed for TNF 238 G/A polymorphism and Type 1 DM (T1DM), 5 of 12 were analyzed for TNF 308 G/A polymorphism and DR in Type 2 DM (T2DM), and 3 of 12 were analyzed for TNF 308 G/A polymorphism and DN in T2DM). Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed or random effects model. The I(2) statistics were used to evaluate between-study heterogeneity. Sensitivity analysis was also performed. RESULTS: The results showed no evidence for significant association between TNF 238 G/A polymorphism and T1DM (for AA + GA versus GG: OR = 0.95, 95% CI = 0.48-1.88, p = 0.89), and also no association between TNF 308 G/A polymorphism and DR and DN risk in T2DM (for AA + GA versus GG: OR = 1.04, 95% CI = 0.87-1.25, p = 0.68; OR = 0.88, 95% CI = 0.71-1.08, p = 0.21; respectively). In addition, the similar results were obtained in the subgroup analysis based on the ethnicity. CONCLUSIONS: In summary, results from this meta-analysis suggest that the TNF 238 G/A polymorphism was not associated with T1DM. No association between TNF 308 G/A polymorphism and DR and DN in T2DM was detected.
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Authors | Nana Meng, Yue Zhang, Hao Li, Jinlan Ma, Yi Qu |
Journal | Current eye research
(Curr Eye Res)
Vol. 39
Issue 2
Pg. 194-203
(Feb 2014)
ISSN: 1460-2202 [Electronic] England |
PMID | 24073796
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tumor Necrosis Factor-alpha
|
Topics |
- Adolescent
- Adult
- Diabetes Mellitus
(genetics)
- Diabetic Nephropathies
(genetics)
- Diabetic Retinopathy
(genetics)
- Female
- Humans
- Male
- Middle Aged
- Odds Ratio
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
(genetics)
- Risk Factors
- Tumor Necrosis Factor-alpha
(genetics)
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