Abstract |
This study compared the predicted effect-site concentration of propofol at loss and recovery of consciousness when using target-controlled infusion devices with the same pharmacokinetic model (Marsh) but a different plasma effect-site equilibration rate constant (ke0 ), the Diprifusor(TM) (ke0 0.26 min(-1) ) and Base Primea™ (ke0 1.21 min(-1) ). We studied 60 female patients undergoing minor gynaecological surgery under general anaesthesia. Although the total dose of propofol and time until loss of consciousness were comparable, the effect-site concentration at loss of consciousness was significantly lower with the Diprifusor than with the Base Primea (1.2 (0.3) μg.ml(-1) vs 4.5 (0.9) μg.ml(-1) , respectively, p < 0.001). The effect-site concentration at recovery of consciousness was significantly higher with the Diprifusor than with the Base Primea (1.8 (0.4) μg.ml(-1) vs 1.5 (0.2) μg.ml(-1) , respectively, p = 0.01). In conclusion, the effect-site concentration of propofol differs depending on the ke0 , despite the use of the same pharmacokinetic model. Therefore, the ke0 should be considered when predicting loss and recovery of consciousness based on the effect-site concentration of propofol.
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Authors | J H Seo, E K Goo, I A Song, S H Park, H P Park, Y T Jeon, J W Hwang |
Journal | Anaesthesia
(Anaesthesia)
Vol. 68
Issue 12
Pg. 1232-8
(Dec 2013)
ISSN: 1365-2044 [Electronic] England |
PMID | 24032636
(Publication Type: Journal Article)
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Copyright | © 2013 The Association of Anaesthetists of Great Britain and Ireland. |
Chemical References |
- Anesthetics, Intravenous
- Propofol
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Topics |
- Adult
- Aged
- Algorithms
- Anesthesia Recovery Period
- Anesthesia, General
(methods)
- Anesthetics, Intravenous
(blood, pharmacokinetics)
- Consciousness
(drug effects)
- Dose-Response Relationship, Drug
- Female
- Gynecologic Surgical Procedures
- Humans
- Infusions, Intravenous
(instrumentation, methods)
- Middle Aged
- Models, Biological
- Propofol
(blood, pharmacokinetics)
- Young Adult
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