The 3q27 and 18q21 translocations for follicular lymphoma and diffuse large B-cell lymphoma in the rituximab era.

Abstract

The 3q27 and 18q21 chromosomal translocations are major hallmarks in B-cell lymphoma. We aimed to determine the frequencies of these translocations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) and to evaluate their prognostic impact in the rituximab era. This study included 98 FL and 93 DLBCL patients whose abnormal karyotypes had been detected using G-banding. Patients uniformly underwent R-CHOP therapy : doxorubicin, cyclophosphamide, vincristine, prednisolone, and rituximab ; survivors were followed up for 29 months (median). The 3q27 and 18q21 translocations were detected in 14 and 77 FL patients and 14 and 22 DLBCL patients, respectively. Overall survival (OS) and progression-free survival (PFS) did not differ significantly between the groups with 3q27, 18q21, concurrent 3q27 and 18q21 translocations, and other chromosomal abnormalities for FL and DLBCL. There were no significant differences in OS and PFS between patients with 3q27 translocation-positive FL and those with 3q27 translocation-positive DLBCL or between the patients with 18q21 translocation-positive FL and those with 18q21 translocation-positive DLBCL. The presence of 3q27 and 18q21 translocations did not correlate with the clinical outcomes of FL or DLBCL patients following R-CHOP treatment.

• Authors: Reina Watanabe, Naoto Tomita, Chihiro Matsumoto, Yukako Hattori, Shiro Matsuura, Hirotaka Takasaki, Chizuko Hashimoto, Hiroyuki Fujita, Shin Fujisawa, Yoshiaki Ishigatsubo
• Journal: Journal of clinical and experimental hematopathology : JCEH (J Clin Exp Hematop) Vol. 53 Issue 2 Pg. 107-14 ( 2013) ISSN: 1880-9952 [Electronic] Japan
• PMID: 23995106 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Antineoplastic Agents
• Rituximab

Topics

• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal, Murine-Derived (administration & dosage, therapeutic use)
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chromosomes, Human, Pair 18
• Chromosomes, Human, Pair 3
• Female
• Humans
• Lymphoma, Follicular (drug therapy, genetics, mortality, pathology)
• Lymphoma, Large B-Cell, Diffuse (drug therapy, genetics, mortality, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Risk Factors
• Rituximab
• Translocation, Genetic
• Young Adult