[Efficacy of actovegin in the treatment of elderly patients with vascular mild cognitive impairment].

Abstract

Efficacy of actovegin was investigated in the treatment of mild cognitive impairment (MCI) of cerebrovascular genesis. Thirty patients (7 men and 23 women, mean age 71.2 years) received actovegin intramuscularly in dosage 5 ml (200 mg) daily during 4 weeks. Patient's were assessed before and after treatment using CGI and MMSE, verbal association test, scale of frontal dysfunction, clock drawing test, Boston naming test, Mattis dementia scale, test to remember 10 words, the Hamilton depression scale. An improvement was seen in all measures. A positive therapeutic effect, including increased speed of mental processes, reduction of bradiphrenia and memory disorders as well as positive impact on asthenic and depressive symptoms, was identified. Side-effects and adverse events of actovegin were not observed. It is concluded that actovegin could be recommended for elderly patients with early manifestations of cognitive decline.

• Authors: N M Mikhaĭlova, N D Selezneva, Ia B Kalyn, I F Roshchina, S I Gavrilova
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 113 Issue 7 Pt 2 Pg. 69-76 ( 2013) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 23994934 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Central Nervous System Stimulants
• Heme
• Actovegin

Topics

• Aged
• Aged, 80 and over
• Central Nervous System Stimulants (administration & dosage)
• Cerebrovascular Disorders (complications, diagnosis, physiopathology)
• Cognition (drug effects)
• Cognitive Dysfunction (diagnosis, drug therapy, etiology)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Heme (administration & dosage, analogs & derivatives)
• Humans
• Male
• Middle Aged
• Neuropsychological Tests
• Psychiatric Status Rating Scales
• Treatment Outcome