Abstract | BACKGROUND: METHODS: After institutional review board approval, 125 morbidly obese patients were recruited into this double-blind placebo-controlled trial. On random division, the patients received a tablet of aprepitant (80 mg) in group A, or a similar-appearing placebo in group P, an hour prior to surgery. All patients received intravenous ondansetron (4 mg) intraoperatively. Postoperatively, the patients were evaluated for nausea and vomiting by a blinded evaluator at 30 min, 1, 2, 6, 24, 48, and 72 h. RESULTS: Both groups were evenly distributed for age, body mass index, type, and length of surgery. Cumulative incidence of vomiting at 72 h was significantly lower in group A (3%) compared to group P (15%; p = 0.021). Odds ratio for vomiting in group P compared to group A was 5.47 times. On Kaplan-Meier plot, time to first vomiting was also significantly delayed in group A (p = 0.019). A higher number of patients showed complete absence of nausea or vomiting in group A compared to group P (42.18 vs. 36.67%). On the other hand, nausea scores were unaffected by aprepitant, and no significant difference between groups was found at any of the measured time points. CONCLUSIONS:
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Authors | Ashish C Sinha, Preet Mohinder Singh, Noel W Williams, Edward Andrew Ochroch, Basavana G Goudra |
Journal | Obesity surgery
(Obes Surg)
Vol. 24
Issue 2
Pg. 225-31
(Feb 2014)
ISSN: 1708-0428 [Electronic] United States |
PMID | 23990451
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiemetics
- Morpholines
- Aprepitant
- Ondansetron
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Topics |
- Adult
- Antiemetics
(therapeutic use)
- Aprepitant
- Bariatric Surgery
(adverse effects)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Laparoscopy
(adverse effects)
- Male
- Middle Aged
- Morpholines
(therapeutic use)
- Obesity, Morbid
(surgery)
- Ondansetron
(therapeutic use)
- Patient Satisfaction
- Postoperative Nausea and Vomiting
(drug therapy, prevention & control)
- Prospective Studies
- Treatment Outcome
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