Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation.
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| Abstract | OBJECTIVE: The objective of this study was to define the radiological characteristics of 2-phase computed tomography (CT) of parotid gland Warthin tumors (WTs) with a pathologic basis for these findings. METHODS: We prospectively enrolled 116 patients with parotid gland tumor who underwent preoperative 2-phase CT scans(scanning delays of 30 and 120 seconds). The attenuation changes and enhancement patterns were analyzed according to pathology. We also evaluated size-matched samples of WTs and pleomorphic adenoma by staining CD31, vascular endothelial growth factor-receptor 2, collagen IV, and smooth muscle actin. RESULTS: Computed tomography numbers in WTs were significantly higher than those in other tumors in early-phase scans and lower in delayed scans. Pathologically, CD31(+) blood vessel area was significantly higher in WTs than in pleomorphic adenomas. In addition, WTs had an extensive capillary network and many leaky blood vessels. CONCLUSIONS: The enhancement pattern of early fill-in and early washout is the typical finding of WTs on 2-phase CT scans, which may be attributed pathologically to abundant blood vessel and extensive capillary network.
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| Authors | Seung Hoon Woo, Dae-Seob Choi, Jin-pyeong Kim, Jung Je Park, Yeon Hee Joo, Phil-Sang Chung, Bo-Young Kim, Young-Hyeh Ko, Han-Sin Jeong, Hyung-Jin Kim |
| Journal | Journal of computer assisted tomography (J Comput Assist Tomogr) 2013 Jul-Aug Vol. 37 Issue 4 Pg. 518-24 ISSN: 1532-3145 [Electronic] United States |
| PMID | 23863526 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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